What is hemoglobin?
Where does your hemoglobin come from?
What is hemoglobinopathy?
What is sickle cell trait?
How will I know if I have sickle cell trait?
Where can I be tested for sickle cell trait?
What is sickle cell disease?
What are "sickle cell conditions"?
How do you get sickle cell anemia or trait?
How common is sickle cell anemia?
How is sickle cell anemia detected?
How is the testing done?
What are the chances of having a baby with sickle cell trait?
What are the chances of having a baby with sickle cell disease?
What medical problems are caused by sickle cell disease?
What should future parents know?
How can I be tested?
What services are available in Missouri for persons with sickle cell conditions?
Where can I get more information about services available in Missouri?
What does DHSS offer for adult sickle cell patients 21 years of age and older?
What services are available in ________ for persons with sickle cell conditions?
Where can I get more information about services available in ________?
What does DHSS offer for adult sickle cell patients 21 years of age and older?
What causes a low hemoglobin count?
Is constantly craving and chewing ice a sign of anemia?
What is hemoglobin?
Hemoglobin (Hb) is the special protein within the red blood cells that carries oxygen from the lungs to the rest of the body. Hemoglobin is what makes your blood look red in color.
Where does your hemoglobin come from?
Your hemoglobin type is inherited through family genes. The color of your hair, the color of your eyes, and your hemoglobin type are all examples of things that are determined by genes. You receive one gene for hemoglobin type from your mother and one from your father. Hemoglobin A or normal adult hemoglobin is the most common type. There are over 500 different types or variations of hemoglobin.
What is hemoglobinopathy?
Hemoglobinopathy is a term used to describe disorders caused by the presence of abnormal hemoglobin production in the blood.
What is sickle cell trait?
Sickle cell trait occurs when a person inherits a normal hemoglobin gene (Hb A) from one parent, and a sickle hemoglobin gene (Hb S) from the other parent. This results in hemoglobin AS or sickle cell trait. A person with sickle cell trait may also be called a sickle cell carrier. Sickle cell trait is not a disease and usually does not affect one's health, but individuals with sickle cell trait can pass the sickle hemoglobin gene to their children.
How will I know if I have sickle cell trait?
A simple blood test called a hemoglobin electrophoresis will detect sickle cell trait. This test will tell if you are a carrier of the sickle cell trait or if you have the disease.
Where can I be tested for sickle cell trait?
Your physician can give you the test or the test may be obtained at some hospitals, sickle cell centers, and health department clinics.
What is sickle cell disease?
Sickle cell disease is a group of inherited blood disorders caused by the presence of hemoglobin S in red blood cells. The red cells change to a sickle (banana) shape and can clog blood vessels causing damage to the body's tissues and organs.
Normal and Sickled Red Blood Cells
Sickle cell anemia (Hb SS) is the most common type of sickle cell disease. There are other hemoglobin types such as hemoglobin C or hemoglobin E, that in combination with the gene for sickle hemoglobin can result in different forms of sickle cell disease (Hb SC, Hb SE, Hb S/beta thalassemia).
What are "sickle cell conditions"?
They are sickle cell trait and the various types of sickle cell disease.
How do you get sickle cell anemia or trait?
You inherit the abnormal hemoglobin from your parents. You cannot catch it from someone else or pass it to another person like a cold or other infections. You are born with sickle cell hemoglobin and it is present for life. If you inherit only one sickle gene, you have sickle cell trait and will not develop the disease. If you inherit two sickle cell genes, you have sickle cell anemia.
How common is sickle cell anemia?
Sickle cell anemia affects millions of people throughout the world. It is particularly common among people whose ancestors come from Africa; Spanish speaking regions (South America, Cuba, Central America); Saudi Arabia; India; and Mediterranean countries, such as Turkey, Greece, and Italy. In the United States, most people who have sickle cell disease are African American. In Missouri, the disease occurs in approximately 1 in every 400 African-American births, and approximately 1 in 12 African Americans carry the sickle cell trait.
How is sickle cell anemia detected?
Most states now perform a blood test for sickle cell disease on all newborn infants. Early diagnosis of sickle cell anemia is critical so that children who have the disease can receive proper treatment. Since May 1989, all babies born in Missouri are tested for sickle cell conditions through the Missouri Newborn Screening Program (MNSP). This test is performed at the same time and from the same blood samples as other routine newborn screening tests. If the test shows the presence of sickle hemoglobin, a second blood test is performed to confirm the diagnosis. These tests also tell whether the child carries the sickle cell trait.
How is the testing done?
A small blood sample is taken from the infant's heel, usually before the baby leaves the hospital. The blood sample will show whether the baby has sickle cell trait, sickle cell disease or any other abnormal hemoglobin.
What are the chances of having a baby with sickle cell trait?
When ONE parent has sickle cell trait and the other parent has normal hemoglobin the child may inherit:
* two normal hemoglobin genes, or
* one normal hemoglobin gene and one sickle cell gene.
One parent with sickle cell trait
With EACH pregnancy there is a:
* 50% chance that the baby will have normal red blood cells (AA).
* 50% chance that the baby will have sickle cell trait (AS).
What are the chances of having a baby with sickle cell disease?
When BOTH parents have sickle cell trait (AS), the child may inherit:
* two normal hemoglobin genes, or
* one normal hemoglobin gene and one sickle cell gene, or
* two sickle cell genes
Both parents with sickle cell trait
With EACH pregnancy there is a:
* 25% chance that the baby's red blood cells will be normal (AA).
* 50% chance that the baby will have sickle cell trait (AS).
* 25% chance that the baby will have sickle cell disease (SS).
What medical problems are caused by sickle cell disease?
Sickle shaped red blood cells tend to get stuck in narrow blood vessels blocking the flow of blood. This can cause damage to organs including the spleen, liver and kidneys. Other complications include pain episodes, lung problems and stroke.
What should future parents know?
People who are planning to become parents should know whether they are carriers of the sickle cell gene. If they are, they may want to seek genetic counseling to find out what the chances are that their child will have sickle cell trait or sickle cell anemia.
How can I be tested?
Your doctor can do a simple blood test called a hemoglobin electrophoresis. This test will tell if you are a carrier of the sickle cell trait or if you have the disease.
What services are available in ________ for persons with sickle cell conditions?
* The Missouri Newborn Screening Program (MNSP) tests newborns for sickle cell and other hemoglobinopathies.
* Family members of infants identified with sickle cell conditions can be screened at county and city health departments, family planning clinics and hospitals.
* Educational genetic counseling is available through the Missouri Sickle Cell Anemia Program (MSCAP) for individuals identified with sickle cell trait or other carrier conditions.
* Educational programs about sickle cell trait and sickle cell disease are available for schools, community groups and other interested groups.
* Hemoglobinopathy (Sickle Cell) Resource Centers are established throughout the State to provide comprehensive services for individuals and families with sickle cell disease. Each resource center is located in a hospital that provides inpatient, outpatient and emergency care.
Where can I get more information about services available in ________?
For more information, contact us.
What does DHSS offer for adult sickle cell patients 21 years of age and older?
The Sickle Cell fact sheet provides information for patients 21 years of age and older.
What causes a low hemoglobin count?
Hemoglobin is the iron-rich protein in red blood cells that gives blood its red color. The normal range of hemoglobin is approximately 14 to 17 grams per deciliter for men and 12 to 16 grams per deciliter for women. A low hemoglobin count indicates a low red blood cell count (anemia). Anemia can have many causes, including:
* Vitamin and iron deficiencies
* Acute or chronic bleeding
* Hormone deficiencies, such as thyroid hormone or testosterone
* Chronic diseases, such as kidney failure, cancer and Crohn's disease
* Autoimmune diseases, such as lupus
* Side effect of certain medications, such as chemotherapy drugs
Is constantly craving and chewing ice a sign of anemia?
Possibly. Doctors use the term "pica" to describe craving and chewing substances that have no nutritional value — such as ice, clay, cornstarch or paper. Transient pica is very common in normal children. On the other hand, craving and chewing ice (pagophagia) is often associated with iron deficiency anemia — although it may be associated with other nutritional problems as well.
It's not known why some people with iron deficiency anemia crave and chew ice. Results from one study suggest it may be because of ice's pain-relieving properties, since some people with iron deficiency anemia experience tongue pain and inflammation (glossitis). The same researchers found that ice has a new and better taste to some people who are iron deficient.
In some individuals, pica is a sign of emotional problems, such as stress, obsessive-compulsive disorder or a developmental disorder.
A thorough medical evaluation can help determine if pica is due to an underlying medical condition. If the cause of pica is an emotional or developmental issue, cognitive behavioral therapy may be helpful.